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MICRO-MAGNETOCARDIOGRAPHY SYSTEM WITH SQUID MAGNETOMETER ARRAY - Rajath.M.Akki - 08-16-2017 MICRO-MAGNETOCARDIOGRAPHY SYSTEM WITH SQUID MAGNETOMETER ARRAY RENJITH . E. R S7 AEI College of engineering , Trivandrum 2007-11 batch Overview Need for MCG Materials Development of SQUID Sensor Noise cancelling system and its evaluation Object table Magnetically Shielded box and Cryostat Total System Method In Vivo Measurement Myocardial Injury Drug induced QT Prolongation Correlation between ECG and MCG Human ECG setup Mouse ECG setup Magneto Cardiography Biomagnetism SQUIDs Baule and McFee QT Analysis David Cohen : Magnetically shielded room Arrhythmia James Zimmerman : SQUID Josephson junction DC Josephson Effect : direct current crossing from the insulator in the absence of any external electromagnetic field, owing to tunneling AC Josephson Effect : With a fixed voltage across the junctions, the phase will vary linearly with time and the current will be an AC current with amplitude Ic and frequency 2e/h * UDC SQUID The basic components of a SQUID System Development of SQUID Sensor 9 channel SQUID Micro magneto meter array 6 sectorial pick up loops connected in parallel to Josephson junction in each SQUID FLL on PCB by flip chip interconnection technology Noise canceling System Evaluation of the Canceling System Cancelling method in analog within the FLL circuit Reference sensor : 2.2mm square pick-up loop ,Signal resolution 40fTHz^(1/2) Effect of noise cancelling : 6dB in time domain ,10 dB and 16 dB at power line frequencies Noise floor increased 10 dB due to white noise Effect on Time and Frequency domain Object Table 3 axis stage to ensure the reproducibility and reliability of the measurement system A detachable plate to fix an object and was equipped with temperature control capability to stabilize the physical condition of the object Magnetically Shielded Box and Cryostat 500mm 300mm 400mm 2 layered magnetic shielding Sensor at the center Cryostat at center and FRP tube houses sensors inside the tube through a hole Total System In Vivo Measurement Myocardial Injury Drug-Induced QT Prolongation Correlation Between ECG and MCG Advantages & Challenges ahead Capability of the newly developed MCG system for clear and real-time measurement of cardiac biomagnetism from small animals such as mice. Possibility of differential diagnosis of posterior myocardial infarction from anterior myocardial infarction in rats, which is sometimes difficult to achieve by means of ECG Magnetocardiography using a large magnetometer array would give a deep insight into current conduction in the heart of small animals MCG measurement of the QT interval correlated well with ECG measurement. No need to put electrodes on the tiny legs or chest of small animals when measuring MCGs References [1] D. Brisinda, A. M. Meloni, and R. Fenici, Contactless magnetocardiographic study of ventricular repolarization in intactWistar rats: Evidence of gender-related differences, Basic Res. Cardiol., vol. 99, no.3, pp. 193 203, 2004. [2] Y. Ono and A. Ishiyama, Non-invasive cardiac functional mapping of disease-model mice: Development of high spatial resolution SQUID system for MCG on mice, J. Cryo. Soc. Jpn., vol. 40, no. 2, pp. 44 50,2005. [3] R. Ackermann, F.Wiekhorst, A. Beck, D. Gutkelch, F. Ruede, A. Schnabel,U. Steinhoff, D. Drung, J. Beyer, C. Assmann, L. Trahms, H.Koch, T. Schurig, R. Fischer, M. Bader, H. Ogata, and H. Kado, Multichannel SQUID system with integrated magnetic shielding for magnetocardiography of mice, IEE Trans. Appl. Supercond., vol. 17, no.2, pp. 827 830, 2007. [4] International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonised Tripartite Guideline S7B: Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals, [Online]. Available: http://ichcache/compo/276-254-1.html [Online]. Available: http://fda.gov/CbER/gdlns/ichqt.htm http://en.wikipediawiki/Magnetocardiography http://en.wikipediawiki/Magnetometer http://en.wikipediawiki/Biomagnetism http://en.wikipediawiki/Josephson_effect http://en.wikipediawiki/SQUID http://freepatentsonline4004217.html |